By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
File from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental stories and Toxicology. quantity 2. Softcover.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2
Glucose-6-phosphate dehydrogenase (G6PD) activity was increased 40% in exposed animals compared with controls from days 1 through 14. Sequential examination every hour during a 7-h exposure revealed lung weights increasing 4 h into the exposure, reaching a maximum elevation of 60% above controls at 6 h. Both the NPSH levels and G6PD activities were decreased in this exposure regimen. Frosolono and Currie (1985) investigated the effect of phosgene on the pulmonary surfactant-system (PSS) in groups of six to 14 rats exposed to phosgene at 1 ppm for 4 h.
75–44–5 Lipsett et al. 1994 Physical state Gas Lipsett et al. 4 (air=1) Lipsett et al. 2°C/not Lipsett et al. 1994; applicable NIOSH 1994 Solubility Decomposes in water and EPA 1986 alcohol; soluble in organic solvents Lipsett et al. 24 ppm Incompatibility Alkalis, ammonia, NIOSH 1997 alcohols, copper Many case reports describe symptomology and postmortem results from human phosgene poisonings; however, exposure concentrations were not reported. Six men were occupationally exposed to phosgene when a pipe ruptured (Stavrakis 1971).
APPENDIX 35 mice were sacrificed on postexposure days 1, 2, 3, 4, 5, 7, 10, or 14. A histopathological examination was performed on the lungs of these animals. Varying degrees of edema, patches of leucocytic infiltration, and bronchial and bronchiolitic epithelia being lifted by edema were observed on postexposure day 1. More severe edema and collapsed lungs with leukocytic infiltration were observed on postexposure days 2–5. The lungs of the remaining mice were essentially normal by postexposure days 10 through 14.