Japanese medium tanks by Tomio Hara

By Tomio Hara

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In recent years, the importance of the intracellular free calcium concentration in the physiology of the cell has been increasingly recognized. Measurement of this substance in cells has been difficult in the past, but the advent of luminescent techniques has opened up new possibilities to define the cellular action of lithium in a more quantitative way. Enzyme effects of lithium have been reviewed by Johnsonll2 and Birch,113 and the reader is referred to these reviews for fuller discussion. The interaction between lithium and enzymes has been investigated in vitro and in vivo, but in many studies, lithium concentrations have borne no relationship to therapeutic levels in human serum, thus making the results difficult to interpret.

Johnson G, Gershon S, Burdock EI, et al: Comparative effects of lithium and chlorpromazine in the treatment of acute manic states. Br J Psychiatry 119:267-276, 1971. 18. Spring G, Schweid D, Gray L, et al: A double-blind comparison of lithium and 26 Chapter 2 chlorpromazine in the treatment of manic states. Am J Psychiatry 126:1306-1310, 1970. 19. Platman SR: A comparison of lithium carbonate and chlorpromazine in mania. Am J Psychiatry 127:351-353, 1970. 20. Prien RF, Caffey EM, Jr, Klett CJ: Relationship between serum lithium level and clinical response in acute mania treated with lithium.

26. Blackwell B, Shepherd M: Prophylactic lithium: another therapeutic myth? An examination of the evidence to date. Lancet 1:968-971, 1968. 27. Shull WK, Sapira JD: Critique of studies of lithium salts in the treatment of mania. Am J Psychiatry 127:218-222, 1970. 28. Angst J, Weiss P, Grof P: Lithium prophylaxis in recurrent affective disorders. Br J Psychiatry 116:604-613, 1970. 29. Melia PI: Prophylactic lithium: a double-blind trial in recurrent affective disorders. Br J Psychiatry 116:621-624, 1970.

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